BIO Protocol
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A new home for Decentralized Biotech. Co-own the medicines of the future.
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Bio Season 2: Building the Future of Permissionless DeSci
It’s time for Bio to evolve from a curated launchpad into a factory for decentralized biotech.
Season 1 of the Bio Launchpad generated a wealth of data and learnings across our first project launches. Over 8,000 participants funded innovations in stem cell research, men’s health, psychedelic science & more.
But despite the traction, it quickly became clear that Season 1 was not designed for scale or sustainability.
Mercenary capital rotated from one sale to another, dumping their allocations post launch.Pairing new project tokens with BIO out of the gate tied network stability to volatile new assets.BioXP incentives skewed too heavily toward short-term participants, reducing the incentive to hold and stake $BIO, the lifeblood of the system.Research funding from trading fees didn’t meet the fundraising needs of biotech founders, undermining efforts to attract world-leading researchers and builders.
We realized if we want Bio to truly change how scientific research gets funded globally, we needed a new model.
Enter Bio Season 2 - engineered to launch and grow a new generation of billion-dollar biotech innovations. The upgrade rebalances power across the ecosystem - transforming Bio into a scalable engine for scientific discovery, where founders access sustainable funding, stakers earn long-term yield, and breakthroughs compound value across the network.
The next phase: a permissionless factory for decentralized biotech.
Key Upgrades:
ASSET/USDC pools: New tokens are paired in pools with USDC, not BIO; ASSET/BIO pools are only added for successful projects that hit and sustain a target FDV.More XP for BIO stakers: We’ve implemented a formula that heavily rewards veBIO (locked BIO) - effectively giving BIO stakers a larger share of XP, especially as more ecosystem tokens are staked.Ecosystem Airdrops: Every new project will airdrop a percentage of its token supply to BIO stakers as a form of passive yield. (Planned to launch after the first wave of Season 2.)Limit-Sell Fundraising: Projects only unlock funding as they achieve market traction. Token sales are automatically executed via limit orders once a project’s FDV remains above preset thresholds, aligning fundraising with real growth.Instant BioXP: Users who need BioXP on short notice will be able to stake and lock BIO to get XP instantly, minus a fast track fee. This provides immediate access to ongoing sales while still locking up BIO. (Planned to launch after the first wave of Season 2.)Aerodrome Pools: All new tokens will launch their liquidity on Aerodrome (via USDC pools), enabling eligible assets to be tradeable on Coinbase from day one.x402 x BioAgents: We’re open-sourcing the BioAgents framework and integrating it with Coinbase’s x402 payments protocol. This will allow DeSci agents to transact seamlessly with each other and with humans, powering onchain agentic commerce across research and health use-cases.BNB Chain Bridge: The BIO token is being bridged to the BNB Chain, extending Bio’s reach into the BNB ecosystem and paving the way for other ecosystem assets to be bridged as well.
The upgraded BioXP formula for BIO stakers will be pushed live in the coming days – meaning going forward, the system will heavily favor BIO stakers.
➤ Stake BIO now to start accumulating BioXP for the next wave of Ignition Sales in Bio Season 2.
I. Launch & Early Trading
USDC/ASSET Pools
After a successful Ignition Sale, newly launched tokens will be paired in an AMM with USDC, instead of BIO. By adding USDC for initial liquidity, we remove the risk of an under-performing token dragging down BIO’s price.Successful assets get an ASSET/BIO pool only once they sustain above a pre-set FDV.This design also allows for tokens to be launched permissionlessly on Bio with ASSET/USDC pools, shielding BIO holders during a project’s volatile early days until it proves it can generate value for the network.
The result: more assets, more scientific domains, more shots on goal to drive value to the ecosystem.
Ecosystem Airdrops
Every Ignition Sale distributes a percentage of the token’s initial supply to BIO stakers, creating a passive form of yield for BIO stakers.Note: Ecosystem airdrops are slated to go live after the first wave of Season 2 launches.
Aerodrome Pool Launcher
New tokens on Bio will launch their ASSET/USDC pool on Aerodrome, using its new pool launcher.Through the integration, any eligible token launching on Bio will trade on Coinbase on day one, expanding accessibility and liquidity.
II. Tokenomics & Fundraising
Limit-Sell Fundraising
Instead of raising a lump sum upfront or relying solely on trading fees, projects unlock funding as they achieve market traction around valuation targets.A percentage of each project’s token supply is reserved to be sold gradually as the project’s market value grows.Sales are made via transparent DEX limit orders once the project’s valuation remains above certain FDV thresholds, continuing to sell incrementally as the token achieves higher valuation milestones.
The result: Project teams receive proceeds only when real market traction occurs, aligning incentives between projects and their token holders.
Project token sales are executed automatically and transparently as the project grows.
Vesting
To encourage stability post-launch, Ignition Sale participants get 20% of their tokens liquid at TGE, while the remaining 80% vests linearly over the next 30 days.By aligning everyone through a brief vesting period, Season 2 aims to create a more stable early market and discourages quick-flip behavior.
III. BioXP
BIO Staking Rewards Increase
Staking BIO now yields a much larger share of BioXP compared to staking ecosystem tokens and other ecosystem activities.In addition, a portion of the total amount of XP generated by ecosystem staking and other activities is redistributed pro rata to BIO stakers. Meaning, the more ecosystem tokens staked on Bio, the more XP BIO stakers collectively earn, connecting network activity with rewards for BIO holders.
Flexible Multipliers for Ecosystem Token Staking
Each ecosystem token can have its XP reward multiplier adjusted individually.This lets the Bio community boost incentives for staking certain tokens - for instance, in a new token’s early days post-launch to bootstrap growth.
Increased Max Allocation
To accommodate stronger conviction and larger capital allocators, users can now purchase up to 1% of a token’s initial supply during its Ignition Sale, up from the previous 0.5% per user max allocation in Season 1.This upgrade allows for deeper liquidity and commitment from larger backers at the token’s inception.
Instant BioXP
What if you discover a live Ignition Sale late and don’t have the BioXP to participate? Season 2 introduces Instant BioXP to solve this.Users can stake BIO, and lock it for a period of time to instantly receive the XP for that timeframe, minus a fast track fee, to use on a live sale.This feature ensures anyone who wants to participate in a sale, including newcomers, a way to jump into a sale immediately, while still bolstering long-term BIO staking.Example: suppose staking a given amount of BIO locked for 2 weeks normally earns you 100 XP; with Instant BioXP, you might stake that BIO and get 60 XP instantly, effectively paying a 40 XP fee for the right to immediately get the XP and use it in a live sale.Note: Instant BioXP is planned to go live after the first wave of Season 2 launches.
IV. Other Changes
x402 x BioAgents
We’re releasing a new open-source version of the BioAgents framework compatible with Coinbase’s x402 payment protocol.This means autonomous science agents in the Bio ecosystem will be able to transact via x402, whether it’s agent-to-agent or agent-to-human payments.A BioAgent could autonomously pay for services like hypothesis evaluation or access to datasets, or sell its analytical outputs, all using onchain x402 transactions.
This integration paves the way for a new era of agent-driven commerce in scientific research.
Binance Smart Chain Bridge
We are building a bridge to connect BIO to Binance Smart Chain, allowing BIO to move into Binance’s ecosystem.This creates an entry point for BSC users and liquidity to flow into Bio, and vice versa.In time, we’ll also establish pathways for other Bio ecosystem tokens to bridge to BSC.
Discoveries at machine speed.
Season 2 is how Bio scales DeSci to the world.
Science should be open. Capital should be agile. Access should be earned.
➤ Stake BIO now to stack BioXP and get ready for the first wave of Season 2 Sales. Coming soon!
Season 1 of the Bio Launchpad generated a wealth of data and learnings across our first project launches. Over 8,000 participants funded innovations in stem cell research, men’s health, psychedelic science & more.
But despite the traction, it quickly became clear that Season 1 was not designed for scale or sustainability.
Mercenary capital rotated from one sale to another, dumping their allocations post launch.Pairing new project tokens with BIO out of the gate tied network stability to volatile new assets.BioXP incentives skewed too heavily toward short-term participants, reducing the incentive to hold and stake $BIO, the lifeblood of the system.Research funding from trading fees didn’t meet the fundraising needs of biotech founders, undermining efforts to attract world-leading researchers and builders.
We realized if we want Bio to truly change how scientific research gets funded globally, we needed a new model.
Enter Bio Season 2 - engineered to launch and grow a new generation of billion-dollar biotech innovations. The upgrade rebalances power across the ecosystem - transforming Bio into a scalable engine for scientific discovery, where founders access sustainable funding, stakers earn long-term yield, and breakthroughs compound value across the network.
The next phase: a permissionless factory for decentralized biotech.
Key Upgrades:
ASSET/USDC pools: New tokens are paired in pools with USDC, not BIO; ASSET/BIO pools are only added for successful projects that hit and sustain a target FDV.More XP for BIO stakers: We’ve implemented a formula that heavily rewards veBIO (locked BIO) - effectively giving BIO stakers a larger share of XP, especially as more ecosystem tokens are staked.Ecosystem Airdrops: Every new project will airdrop a percentage of its token supply to BIO stakers as a form of passive yield. (Planned to launch after the first wave of Season 2.)Limit-Sell Fundraising: Projects only unlock funding as they achieve market traction. Token sales are automatically executed via limit orders once a project’s FDV remains above preset thresholds, aligning fundraising with real growth.Instant BioXP: Users who need BioXP on short notice will be able to stake and lock BIO to get XP instantly, minus a fast track fee. This provides immediate access to ongoing sales while still locking up BIO. (Planned to launch after the first wave of Season 2.)Aerodrome Pools: All new tokens will launch their liquidity on Aerodrome (via USDC pools), enabling eligible assets to be tradeable on Coinbase from day one.x402 x BioAgents: We’re open-sourcing the BioAgents framework and integrating it with Coinbase’s x402 payments protocol. This will allow DeSci agents to transact seamlessly with each other and with humans, powering onchain agentic commerce across research and health use-cases.BNB Chain Bridge: The BIO token is being bridged to the BNB Chain, extending Bio’s reach into the BNB ecosystem and paving the way for other ecosystem assets to be bridged as well.
The upgraded BioXP formula for BIO stakers will be pushed live in the coming days – meaning going forward, the system will heavily favor BIO stakers.
➤ Stake BIO now to start accumulating BioXP for the next wave of Ignition Sales in Bio Season 2.
I. Launch & Early Trading
USDC/ASSET Pools
After a successful Ignition Sale, newly launched tokens will be paired in an AMM with USDC, instead of BIO. By adding USDC for initial liquidity, we remove the risk of an under-performing token dragging down BIO’s price.Successful assets get an ASSET/BIO pool only once they sustain above a pre-set FDV.This design also allows for tokens to be launched permissionlessly on Bio with ASSET/USDC pools, shielding BIO holders during a project’s volatile early days until it proves it can generate value for the network.
The result: more assets, more scientific domains, more shots on goal to drive value to the ecosystem.
Ecosystem Airdrops
Every Ignition Sale distributes a percentage of the token’s initial supply to BIO stakers, creating a passive form of yield for BIO stakers.Note: Ecosystem airdrops are slated to go live after the first wave of Season 2 launches.
Aerodrome Pool Launcher
New tokens on Bio will launch their ASSET/USDC pool on Aerodrome, using its new pool launcher.Through the integration, any eligible token launching on Bio will trade on Coinbase on day one, expanding accessibility and liquidity.
II. Tokenomics & Fundraising
Limit-Sell Fundraising
Instead of raising a lump sum upfront or relying solely on trading fees, projects unlock funding as they achieve market traction around valuation targets.A percentage of each project’s token supply is reserved to be sold gradually as the project’s market value grows.Sales are made via transparent DEX limit orders once the project’s valuation remains above certain FDV thresholds, continuing to sell incrementally as the token achieves higher valuation milestones.
The result: Project teams receive proceeds only when real market traction occurs, aligning incentives between projects and their token holders.
Project token sales are executed automatically and transparently as the project grows.
Vesting
To encourage stability post-launch, Ignition Sale participants get 20% of their tokens liquid at TGE, while the remaining 80% vests linearly over the next 30 days.By aligning everyone through a brief vesting period, Season 2 aims to create a more stable early market and discourages quick-flip behavior.
III. BioXP
BIO Staking Rewards Increase
Staking BIO now yields a much larger share of BioXP compared to staking ecosystem tokens and other ecosystem activities.In addition, a portion of the total amount of XP generated by ecosystem staking and other activities is redistributed pro rata to BIO stakers. Meaning, the more ecosystem tokens staked on Bio, the more XP BIO stakers collectively earn, connecting network activity with rewards for BIO holders.
Flexible Multipliers for Ecosystem Token Staking
Each ecosystem token can have its XP reward multiplier adjusted individually.This lets the Bio community boost incentives for staking certain tokens - for instance, in a new token’s early days post-launch to bootstrap growth.
Increased Max Allocation
To accommodate stronger conviction and larger capital allocators, users can now purchase up to 1% of a token’s initial supply during its Ignition Sale, up from the previous 0.5% per user max allocation in Season 1.This upgrade allows for deeper liquidity and commitment from larger backers at the token’s inception.
Instant BioXP
What if you discover a live Ignition Sale late and don’t have the BioXP to participate? Season 2 introduces Instant BioXP to solve this.Users can stake BIO, and lock it for a period of time to instantly receive the XP for that timeframe, minus a fast track fee, to use on a live sale.This feature ensures anyone who wants to participate in a sale, including newcomers, a way to jump into a sale immediately, while still bolstering long-term BIO staking.Example: suppose staking a given amount of BIO locked for 2 weeks normally earns you 100 XP; with Instant BioXP, you might stake that BIO and get 60 XP instantly, effectively paying a 40 XP fee for the right to immediately get the XP and use it in a live sale.Note: Instant BioXP is planned to go live after the first wave of Season 2 launches.
IV. Other Changes
x402 x BioAgents
We’re releasing a new open-source version of the BioAgents framework compatible with Coinbase’s x402 payment protocol.This means autonomous science agents in the Bio ecosystem will be able to transact via x402, whether it’s agent-to-agent or agent-to-human payments.A BioAgent could autonomously pay for services like hypothesis evaluation or access to datasets, or sell its analytical outputs, all using onchain x402 transactions.
This integration paves the way for a new era of agent-driven commerce in scientific research.
Binance Smart Chain Bridge
We are building a bridge to connect BIO to Binance Smart Chain, allowing BIO to move into Binance’s ecosystem.This creates an entry point for BSC users and liquidity to flow into Bio, and vice versa.In time, we’ll also establish pathways for other Bio ecosystem tokens to bridge to BSC.
Discoveries at machine speed.
Season 2 is how Bio scales DeSci to the world.
Science should be open. Capital should be agile. Access should be earned.
➤ Stake BIO now to stack BioXP and get ready for the first wave of Season 2 Sales. Coming soon!
AI-driven biology is exploding, with giants like Google, OpenAI and Stanford University building scientific agents that read papers, generate hypotheses & design experiments.
But these tools remain siloed in Web2 - disconnected from capital, coordination & shared knowledge.
BioAgents break these barriers by integrating onchain features for data sharing, experiment funding & discovery monetization.
Experiments can start immediately once vetted, rather than languishing in traditional grant cycles, while BioAgents read and write to a decentralized knowledge graph integrated across the Bio network.
Stay tuned for more details on the first BioAgent launches, powered by $BIO
But these tools remain siloed in Web2 - disconnected from capital, coordination & shared knowledge.
BioAgents break these barriers by integrating onchain features for data sharing, experiment funding & discovery monetization.
Experiments can start immediately once vetted, rather than languishing in traditional grant cycles, while BioAgents read and write to a decentralized knowledge graph integrated across the Bio network.
Stay tuned for more details on the first BioAgent launches, powered by $BIO
Science is entering its Agentic Era
Introducing the Scientific AI Ecosystem Map! 🗺️
We mapped the tools, models & agentic frameworks powering the new substrate for bio
Built to help founders, researchers & builders navigate the explosion in scientific AI
Let’s break it down🧵
Introducing the Scientific AI Ecosystem Map! 🗺️
We mapped the tools, models & agentic frameworks powering the new substrate for bio
Built to help founders, researchers & builders navigate the explosion in scientific AI
Let’s break it down🧵
The fiat system says lose a little of your wealth every year.
The medical system says lose a little of your health every year.
Crypto and longevity say: what if we reject both?
cc @balajis @VitalikButerin @thenetworkstate
The medical system says lose a little of your health every year.
Crypto and longevity say: what if we reject both?
cc @balajis @VitalikButerin @thenetworkstate
A new coordination layer for science has entered the system.
bio/acc
bio/acc
We’re designing new ways to get rewarded for supporting the Bio ecosystem.
A reimagining of how scientific knowledge is incentivized 👾
Sneak peek of what’s coming 👀
A reimagining of how scientific knowledge is incentivized 👾
Sneak peek of what’s coming 👀
A new canvas has arrived for scientists to accelerate discovery.
“Independence is the ability to build.”
Today we celebrate not just freedom, but the freedom to create, experiment, and launch new worlds.
Science deserves independence too.
Let’s build systems where innovation doesn’t need permission.
Happy Independence Day 🇺🇸
Today we celebrate not just freedom, but the freedom to create, experiment, and launch new worlds.
Science deserves independence too.
Let’s build systems where innovation doesn’t need permission.
Happy Independence Day 🇺🇸
Launchpad models are stuck in 2017.
Raise big. List fast. Exit early.
At #DeSciBerlin, Bio Protocol CPO @cl2pp shared a better path: one that rewards traction instead of hype.
Here’s the breakdown 🧵
Raise big. List fast. Exit early.
At #DeSciBerlin, Bio Protocol CPO @cl2pp shared a better path: one that rewards traction instead of hype.
Here’s the breakdown 🧵
We’re not here to play by the old rules.
We’re here to write new ones.
Science moves faster when the system does.
We’re here to write new ones.
Science moves faster when the system does.
Building the new substrate for life sciences.
One that’s open, verifiable, and unstoppable.
One that’s open, verifiable, and unstoppable.
Brain science is broken.
Treatments take a decade.
Success rates are near zero.
Here's how @eboyden3's MIT lab used DeSci to engineer a series of "serendipitous" brain health breakthroughs 🧵
Treatments take a decade.
Success rates are near zero.
Here's how @eboyden3's MIT lab used DeSci to engineer a series of "serendipitous" brain health breakthroughs 🧵
Code, cells, capital...moving in sync
bio/acc loading
the DeSci trenches are ready
the DeSci trenches are ready
“9 gov grants rejected. Most places turned me down. Only dumb luck got us funded.”
At #DeSciBerlin, @eboyden3 posed a bold question to every scientist, founder and builder in the room:
Can we engineer serendipity?
This talk was something else 🧵👇
At #DeSciBerlin, @eboyden3 posed a bold question to every scientist, founder and builder in the room:
Can we engineer serendipity?
This talk was something else 🧵👇
Reverse engineer biological feedback loops
Rage against the bureaucratic scientific empire
Rage against the bureaucratic scientific empire
Bio x AI Hackathon Winner Announcements
Announcing the Bio x AI Hackathon Winners 🥁
Over 60 teams built scientific agents in Bio's 2-month virtual hackathon.
We're thrilled to unveil the winners of $125K in prizes - projects pushing the frontier of Decentralized Agentic Science!
Meet the winning projects👇🧵
Over 60 teams built scientific agents in Bio's 2-month virtual hackathon.
We're thrilled to unveil the winners of $125K in prizes - projects pushing the frontier of Decentralized Agentic Science!
Meet the winning projects👇🧵
60 days. $125K in prizes. 60 teams building scientific agents.
Join us TOMORROW as we announce the winners of the Bio x AI Hackathon!
🤖 Live demos
👾 Panel on scientific agents w/ @elizaOS, @origin_trail & more
🎽 Win Bio swag for voting on the winners
How to vote 💻 👇
Join us TOMORROW as we announce the winners of the Bio x AI Hackathon!
🤖 Live demos
👾 Panel on scientific agents w/ @elizaOS, @origin_trail & more
🎽 Win Bio swag for voting on the winners
How to vote 💻 👇
Over 60+ agentic science prototypes submitted in the Bio x AI Hackathon!
From modular MCP servers to VR tools for drug discovery, we were blown away by the creativity 🧪👾
Built with decentralized tech from Bio, @Molecule_dao, @elizaOS, @PrimeIntellect, @solana, @origin_trail & more!
Check out some of the project submissions in the link below and join our livestream this TUESDAY June 17 where winners of $100K+ in prizes will be announced!
From modular MCP servers to VR tools for drug discovery, we were blown away by the creativity 🧪👾
Built with decentralized tech from Bio, @Molecule_dao, @elizaOS, @PrimeIntellect, @solana, @origin_trail & more!
Check out some of the project submissions in the link below and join our livestream this TUESDAY June 17 where winners of $100K+ in prizes will be announced!
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