#BinanceSqaure It's important to note that predicting which specific cryptocurrencies may achieve a 1000x return is highly speculative. However, some coins or tokens that are gaining attention for their innovative approaches and potential in the coming years include:

1. **Polkadot (DOT)**: Versatile technology designed for interoperability between blockchains.

2. **Avalanche (AVAX)**: Known for its fast transactions and robust ecosystem for decentralized apps.

3. **Solana (SOL)**: Offers high throughput and low fees, making it a favorite for developers.

4. **Chainlink (LINK)**: A leader in providing real-world data to smart contracts, essential for many projects.

5. **New DeFi Projects**: Keep an eye on emerging DeFi coins that address unique challenges in the financial space.

Always perform thorough research and consider the risks involved before investing.