• Ethereum is demonstrating significant institutional purchases, enhancing its role as a store of value.
• XRP was used in a $50 million pharmaceutical deal for instant payments to suppliers.
• Solana, Sui, and Supra are competing for the title of the next leading blockchain platform.
Bitcoin has surpassed the $100,000 mark and is currently trading around $104,000. This surge is also leading to an increase in altcoins; some are now testing key resistance levels held for weeks. Amid this bullish market activity, crypto analyst Altcoin Daily shared a list of 14 altcoins that could break out in May 2025. First, three coins from his selection are in the top ten by market capitalization:
Altcoin Daily's market cap selection for a rally in May 2025
1. Ethereum (ETH)
Ethereum is showing strength again. In the last 24 hours, ETH has surged, and institutions are joining in greater adoption of ETH.
Coinbase added 21,000 ETH to its treasury last quarter, now holding over 140,000 ETH worth around $315 million. Institutions launching level 2 networks like Kraken, Worldcoin, and Uniswap are also adopting ETH as a treasury asset, pushing Ethereum further into the 'store of value' category.
Related: Is the altcoin season approaching? A 20% breakthrough for Ethereum could be the spark
1. XRP
XRP is gaining momentum, this time in the pharmaceutical sector. Wellgistics Health from Florida is integrating XRP for real-time payments to suppliers in a $50 million deal. The speed of XRP (settlement within 3–5 seconds) and improved transparency from U.S. regulators are contributing to XRP's adoption in business.
Related: Price forecast $XRP : a breakthrough of $2.36 is crucial for the rally on May 11 to $3
3. Cardano (ADA)
Cardano is forging its own path by integrating with Bitcoin and creating a unique infrastructure.
His partner project, World Mobile Token, expands connectivity in ecosystems and may soon become a 'partner chain' on Cardano's Midnight platform. Founder Charles Hoskinson expressed strong support.
11 additional altcoins marked for a rally in May 2025
Ondo Finance is working with major names like BlackRock to move real assets like bonds onto the blockchain. They also met with the SEC's crypto team.
The BORG token supports the SwissBorg platform, which includes exchanges and crypto tools. A large portion of its supply is staked or locked, and it is expanding to Hyperliquid, called 'Binance DEX'.
COTI started on Cardano and is now operating on Ethereum. It focuses on privacy and real assets and collaborates with the European Central Bank and governments in Africa and the Middle East.
Foxy is a meme coin connected to the Linea network (Ethereum Layer 2). It's still early, but people are talking about it due to its cute branding and growing community.
Chainlink (LINK) remains an important project linking real data to blockchains amidst the merging of cryptocurrencies and traditional finance.
Blockchains like Solana, Sui, and Supra are rapidly growing. Injective offers tokenized U.S. stocks, Paid Network simplifies crypto crowdfunding, and RSC (ResearchHub), backed by the CEO of Coinbase, uses blockchain for scientific research.