#BinanceHODLerSIGN seems to combine a few ideas:

Binance: a major cryptocurrency exchange.

HODLer: slang for someone who holds (doesn’t sell) their crypto, even during market dips.

SIGN: this could refer to a token, project, or signal related to Binance or holding crypto.

It might mean a movement or campaign where Binance users who are long-term holders ("HODLers") are showing support or taking a stand—possibly encouraging others to HODL too.