For general trading and liquidity, $ADA /USDT (Cardano against Tether) is often considered the best pair. USDT is a stablecoin pegged to the US dollar, making it a reliable benchmark for ADA's price movements without the added volatility of another cryptocurrency. This pair consistently boasts the highest trading volumes on major exchanges like Binance and HTX, ensuring easy entry and exit from trades.

While ADA/BTC (Cardano against Bitcoin) is also popular, it introduces the volatility of Bitcoin into the equation, making it more complex for some traders. For long-term investors, ADA/USDT or even direct ADA/USD pairs offer a straightforward way to track and invest in Cardano's performance.