Here are some random important tips.
*If you have already reached 3x to 5x profits, start to take some profits. I might say 10% or 20% of your portfolio.
*Don't be greedy.
*In every bull run, people conceive the market as it will not fall again but it will down dramaticaly who knows when.
*Don't bond emotional connection with a coin. Sell it !!
*Never buy a coin which is already incereased significantly. I don't suggest but you may wait a correction it's up to you.
*Don't reinvest your profit. Otherwise you won't escape from the market.