Research published in Aging Cell identifies LAMP1 as a cell-surface biomarker for senescent cells, funded by @vita_dao.

🎯Key findings:

- LAMP1 expression correlates with established senescence markers (p16, p21)

- Surface LAMP1+ cells increase with age in mouse organs (2-3x higher in older mice)

- In bleomycin-induced lung fibrosis, LAMP1+ cells increased from 6% to 23%

- Antibody-drug conjugate targeting achieved selective senescent cell elimination in culture

The research provides a new tool for identifying and potentially targeting senescent cells in aging and disease.