DeSCI is not just a transfer of science to Web3, but a complex transformation of the scientific infrastructure that faces technical, legal, and social challenges.

1. Technical nuances

a) Data vs. Metadata

- Problem: Blockchain is not suitable for storing large scientific data (e.g., genomic sequences or raw experimental data).

- Solution:

- Only hashes and metadata (authorship, date, experiment conditions) are recorded on the blockchain.

- The data itself is stored in IPFS, Filecoin, Arweave, or decentralized databases (Ceramic, GunDB).

b) Reproducibility and smart contracts

- Problem: Even with methodology recorded on the blockchain, physical experiments may depend on external factors (purity of reagents, calibration of equipment).

- Solution:

- Oracle services (e.g., Chainlink) for verifying real data.

- NFT protocols for equipment (e.g., tokenized access to a laboratory with parameter fixation).

### c) Privacy vs. Transparency

- Conflict: Scientists may be reluctant to disclose intermediate data due to the risk of plagiarism or commercial secrecy.

- Trade-offs:

- Zero-Knowledge Proofs (ZKP): Proof of data correctness without revealing the data itself.

- Partial encryption: For example, access to data through NFT keys.

2. Economic and legal nuances

a) Tokenization of science

- Problem: How to assess a scientist's contribution? Traditional metrics (Hirsch index) do not work in token economics.

- Models:

- Reputation Tokens (non-fungible, e.g., POAP for peer review).

- Profit-Sharing Tokens (scientists receive a share from the commercialization of their research).

b) Regulatory risks

- Publications: In some jurisdictions, NFT articles may not be recognized as official publications.

- Patents vs. Decentralization: If research is recorded in a public blockchain, it may be considered "disclosed" and unsuitable for patenting.

c) Funding through DAO

- Problem: Most DAOs do not have legal status to enter into contracts with universities.

- Workarounds:

- Creating legal wrappers (e.g., Swiss funds for VitaDAO).

- Hybrid DAO — part of the decisions is made off-chain through traditional legal entities.

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3. Social and cultural barriers

a) Conservatism of the scientific community

- Problem: Scientists are accustomed to traditional journals (Nature, Science) and fear "unreliable" Web3 platforms.

- Ways to adapt:

- Partnerships with peer-reviewed journals (e.g., integration of ORCID with NFT publications).

- Hybrid models (e.g., traditional publication + duplication in blockchain).

b) Long-term motivation

- Risk: DeSCI participants may focus on "quick tokens" rather than fundamental research.

- Balance:

- Long-term staking mechanisms (e.g., tokens are unlocked only after confirming results).

- Subsidizing "unpopular" areas through DAO voting.

4. Integration with Minima

Minima can solve some of the DeSCI problems by:

- Lightweight nodes: Scientists can run their nodes without significant costs.

- P2P coordination: Direct data exchange between laboratories without intermediaries.

- Micropayments: For example, payment for real-time access to data.

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Conclusion

DeSCI is not just "science on the blockchain", but a complex ecosystem where technologies must consider:

✅ Technical limitations (data, privacy).

✅ Economic models (tokenization, DAO).

✅ Legal frameworks (patents, publications).

✅ Cultural habits of scientists.

If your interest is related to a specific aspect (e.g., how Minima can store scientific metadata or work with DAOs), let me know — I will explain in more detail! 🔍