By the end of 2025, Semler Scientific plans to own a total of 10,000 bitcoins, by the end of 2026 — 42,000 BTC, and by 2027 — 105,000 BTC. Semler Scientific first acquired bitcoins in May 2024. At that time, the company announced that it would continue to buy and hold the flagship cryptocurrency with a long-term perspective. Since then, it has acquired more than 3,800 BTC, which has allowed the firm to take 13th place in the ranking of corporate bitcoin holders. At the top of the list is the company Strategy by Michael Saylor.

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