$USDC

The top coin pair with USDC right now is BTC/USDC—a go-to for stablecoin-to-crypto traders. It offers deep liquidity, minimal slippage, and robust infrastructure support – a staple on major exchanges like Binance, Kraken, Bybit, and KuCoin .

Next strongest is ETH/USDC, with high trading volume, low volatility, and widespread DeFi integration . These pairs shine for arbitrage, hedging, and efficient entry/exit in crypto markets. Bonus contenders include USDC/USDT for stablecoin arbitrage and XRP/USDC for liquidity on altcoin platforms .