At this time, you can only play the mainstream of each sector; at least that's the case for DeFi. Attention is too scattered in this cycle, and alpha opportunities that rely on small investments to gain large returns have all been captured by memes, making it very difficult for smaller assets in other sectors to survive.
Unless it's a groundbreaking innovation, like the level of AMM during DeFi Summer, if you think there is one, feel free to discuss.