$USDC USDC is originally present in 10 blockchains: Ethereum, Solana, Avalanche, TRON, Algorand, Stellar, Flow, Hedera, Base, and Optimism, and more native integrations are expected this year and beyond. USDC has also been associated with Polygon, Fantom, NEAR, Arbitrum, the Cosmos ecosystem, and many other new blockchains.