$##The "best" coin pair with USDC really depends on your trading goals, platform, and risk appetite. That said, two of the most popular and liquid pairs are:

**USDC/ETH Pair**

Pairing USDC with Ethereum (ETH) is very common because ETH not only has high liquidity but is also central to the decentralized finance (DeFi) ecosystem. Trading through the USDC/ETH pair gives you access to a wide range of DeFi applications and trading opportunities across multiple platforms and blockchains.

**USDC/BTC Pair**

Another frequently traded option is USDC paired with Bitcoin (BTC). This pair allows you to quickly switch between a stable asset (USDC) and the most established cryptocurrency in the world. The high liquidity in the USDC/BTC pair makes it attractive for traders looking to hedge or capitalize on market movements.

*Additional consideration:*

Some platforms also offer stable-stable pairs (like USDC/USDT), but note that on some exchanges—like Coinbase—USDC trading pairs have been removed or limited, forcing users to convert to other stablecoins if they want to trade against volatile assets.

In summary, for most traders looking to use USDC as a stable base, pairing it with ETH or BTC tends to offer the best liquidity and market access.