Research published in Aging Cell identifies LAMP1 as a cell-surface biomarker for senescent cells, funded by @vita_dao.
🎯Key findings:
- LAMP1 expression correlates with established senescence markers (p16, p21) - Surface LAMP1+ cells increase with age in mouse organs (2-3x higher in older mice) - In bleomycin-induced lung fibrosis, LAMP1+ cells increased from 6% to 23% - Antibody-drug conjugate targeting achieved selective senescent cell elimination in culture
The research provides a new tool for identifying and potentially targeting senescent cells in aging and disease.
.@vitarnabio/ @artanbio partners with @Syenex to accelerate ARTAN-102 delivery using the VivoCell Platform! This collab combines:
> VitaRNA's codon suppressor tech targeting age-related mutations > Syenex's precision in vivo delivery expertise
The goal? Speed up the path from proof-of-concept to IND-enabling studies while staying capital-efficient 💊
Led by CSO Dr. Michael Torres ( @Mykalt45), the team's recent safety data shows ARTAN-102 reaches multiple tissues (liver, heart, lung, brain) with no adverse events in mice. 🐭
Next up: Non-human primate studies as they push toward human trials!