Japanese scientists have started testing a new drug in humans that could regrow real teeth — offering a natural alternative to implants and dentures. The drug, called TRG-035, blocks a protein known as USAG-1, which normally stops teeth from developing.

In animal tests, the drug activated dormant tooth buds and led to new tooth growth in mice and ferrets. Now, the first human trial at Kyoto University Hospital is underway with 30 adults aged 30 to 64 who are missing at least one tooth. This phase is focused on making sure the drug is safe.

If it passes safety tests, the next step will be trials in children who were born without permanent teeth. Scientists hope to make this treatment available to the public by 2030 — a major breakthrough in dental care that could replace artificial implants with real tooth regrowth.

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